Effect of an enamel matrix protein derivative (Emdogain®) on ex vivo dental plaque vitality
International scientific review - Basic research
Periodontology
Aim of the study
To observe the effect of Emdogain on the vitality of ex vivo supragingival plaque and to compare its effect with that of 0.2 % chlorhexidine (CHX). The study was carried out as a result of the clinical observation of reduced inflammation and better healing at sites where Emdogain® had been used.
Materials and methods
Twenty-four patients suffering from adult periodontitis abstained from brushing...
Aim of the study
To observe the effect of Emdogain on the vitality of ex vivo supragingival plaque and to compare its effect with that of 0.2 % chlorhexidine (CHX). The study was carried out as a result of the clinical observation of reduced inflammation and better healing at sites where Emdogain® had been used.
Materials and methods
Twenty-four patients suffering from adult periodontitis abstained from brushing for 4 days. At day 5, plaque biofilm samples were taken from each patient. The plaque was divided into 5 parts and subject to the following treatments for 2 minutes : NaCl, enamel matrix derivative dissolved in water, Emdogain®, vehicle PGA and 0.2 % CHX. Plaque vitality was assessed.
Results
The mean vitality of plaque was significantly reduced by Emdogain®, PGA and CHX. The effect of Emdogain® seems to be linked to PGA.
Conclusion
Emdogain® might have antibacterial activity on ex vivo dental plaque.
Commentary
The in vivo activity still has to be assessed.
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