PMN responses following use of 2 biodegradable GTR membranes - JPIO n° 2 du 01/05/2002
 


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Journal de Parodontologie & d'Implantologie Orale n° 2 du 01/05/2002

 

PMN responses following use of 2 biodegradable GTR membranes

International scientific review - Clinical research

Periodontology

M Kebir-Quelin*   E Steimlé**  

Aim of the study

To evaluate PMN responses after placing biodegradable guided tissue regeneration (GTR) membranes in Class 2 mandibular furcation lesions.

Materials and methods

Ten Class 2 buccal furcation on first mandibular molars were treated by GTR. The membranes used were either polylactic-citric-acid-ester (PLA, Guidor®) or glycolide-lactic-co-polymer (PGL, Polyglactine 910). The inflammatory response of PMNs was...


Aim of the study

To evaluate PMN responses after placing biodegradable guided tissue regeneration (GTR) membranes in Class 2 mandibular furcation lesions.

Materials and methods

Ten Class 2 buccal furcation on first mandibular molars were treated by GTR. The membranes used were either polylactic-citric-acid-ester (PLA, Guidor®) or glycolide-lactic-co-polymer (PGL, Polyglactine 910). The inflammatory response of PMNs was assessed at day 0 then each week for 6 weeks and then at 12 and 24 weeks, using gingival fluid ß-glucuronidase and ß -N-acetyl-hexosaminidase.

Results

The levels of enzymes increased between 0 and 6 weeks. After this period, they reduced to their initial value by 12 to 24 weeks. This reduction was more rapid when PGL membranes were used. Both membranes clearly showed an improvement in the clinical parameters following treatment.

Conclusion

The release of enzymes from PMNs after the use of GTR membranes reflects early gingival healing. These results suggest a membrane-dependent response. However, the host response did not affect the course of clinical healing.

Commentary

Theoretically, the mechanism of biodegradation by hydrolysis is not affected by the inflammatory processes.

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